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() () 0- (0-) D. melanogaster Canton-S (C-S) whiteC-S (wC-S), whiteapricotC-S (waC-S), whitesatsumaC-S (wstC-S) (1,3,7, ) .

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SAVORY ESSENTIAL OIL MIGHT BE PERSPECTIVE ADAPTOGEN Vorobyova A.K., Fatkullina L.D., Misharina T.A., Erochin V.N., Burlakova E.B., Terenina M.B.

Emanuel Institute of Biochemical Physics RAS;

4 Kosygin Street, Moscow, 119334 Russia vorobyova.85@mail.ru Its well known that constantly deteriorating ecological situation in megasities is ministerial to occurrence of many diseases from allergosis to cardiovascular and neurogenerative disorders, cancer and also reduces life span of human population. On solving environmental problems plant essential oils (EO) may be hopeful protective agents that possess antioxidant activity, low toxicity and may increase resistance to corrosive air of the town. Therefore, elucidation of the mechanisms of adaptogenic action of EO is urgent now.

In the previous experiments it was found that long-term ingestion of savory essential oil led to increased value of average life span in mice with leukemia (E.B.Burlakova, V.N. Erochin et all., 2010, in press). In this regard we studied the in vivo effect of savory essential oil Satureja hortensis L., added to the drinking water in the dose of 0.15 mg/l on the parameters of oxidative stress in AKR mice. In control group of leukemia mice drank plain water.

It was observed that prolonged ingestion of essential oil led to decreasing of hemolysis level and the number of TBA-reactive products of lipid peroxidation in erythrocytes in the case of prolonged administration. Addition of EO also affected the structural state (microviscosity) of lipids from different regions of erythrocyte membranes (method of EPR-spectroscopy with paramagnetic spin probes) that indicates ability of EO to modify the structural state of cell membranes. The investigation of fatty acids composition of the liver cells (by the GLC method) showed that addition of EO kept on amount of SFA and at the same time decreased number of MUFA. Actually it means the increasing of PUFA total amount and so we can suggest that savory EO has tendency to stabilize the ratio of saturated and unsaturated fatty acids in the lipids of liver cells maintaining antioxidant status of mice on a high level. Thus, we have first obtained results that gave us grounds for supposing EO of Satureja hortensis to possess ability in increasing resistance to oxidative stress as well as inhibiting the leukemic process.

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Babenko N.A......................25 .......................29 ...................... Burlakova E.B.....................75 ........................19 .................... Carey J.R.............................70 ................26 .............................. Erochin V.N........................75 ......................67 ........................ Fatkullina L.D.....................75 .......................21 ............................... Lemeshko V.V....................24 .......... 14, 46 ..................... Loay Khaled Mohammad ...............33 ................. 36, Hassouneh.......................25 ....................23 ....................... Misharina T.A.....................75 ....................73 ................. Terenina M.B......................75 .............................53 .......... 51, Vorobyova A.K..................75 - .........67 ........................ ............. 19, 69, 72 ....................... ..................... .......................43 ............... ...............72 .................... ....................... ...................... 4 .............................. .....................67 ........................... .................69 ..................32 .................... .................15 .............. .................58 ................. 56, .......................... 9 .......................... ............................. ...........................67 ................... 39, ................47 .................... ..............47 ......................... ................ ....................... ........................ ............. 39, ..................... ....................46 ...................... .................. 10, 31 ..................... ..................... 16, 28 ...............73 ........................ .................67 ..................59 ..................... ........................57 ............ 17, ................. 19, 69 .................. 14, ............ 43, 62 ..................... ............. ......................14 .................... ...................... .................... ................ .............................. .......................... ................ ........................ ..................... .......................... ..................... - ..

........... 14, 36 .............................................................. ....................... 4 ....................... ................... .......................62 ......................... .............. 39, .................50 ... 22, 41, 49, .................. 46, 53 ............................. .....................36 .....................31 .......................... ........................56 ......................... ........................60 ........... 71, ................. .......................53 ........ 13, .................... ...................15 ...................... ....................... ..................... ...................61 ............................. ................... .................. ................. ............... .......................... ........................... ................ 37, 56 ......................... .......................... ........................ .......................... .......................18 ......................... ....................... ..............43 ......................... ........... 71, ............................60 ............................ ......... ...........................43 .................... .......................57 ...................... .....................10 ............... ....................... ................71 ................. ................... ....................50 ....................... ....................... .......................... ....................... ...................... ....................... .............. 11, .....................67 ..................... .......... 20, 21, ..................... ............ 36, 39, .................... 14.05.2010. .

6084/8. . . . 4,01. 150 . , 61077, . , . , ..

61124, . , . 6, . 267, ./: (0572) 52-82-

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