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6 0. T r e a t m e n t o u t c o m e a n d prognostic factors for infants with acute l y m p h o b l a s t i c leukemia treated o n t w o c o n s e c u t i v e trials of the Children C a n c e r G r o u p / G. H. R e a m a n [et al.] // J. Clin. O n c o l o g y. - 1999. - V o l. 17. - P. 4 4 5 - 4 5 5.

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c o r r e l a t i o n with m o r p h o l o g y, type of P M L g e n e b r e a k - p o i n t a n d clinical o u t c o m e : a c o o p e r a t i v e Italian study on 196 c a s e s / C. G u g l i e m i [et al.] // Br. J. H a e m a t o l. 1 9 9 8. - V o l. 102. - P. 1 0 3 5 - 1 0 4 1.

199. ( - ) / . . [ . ] // / . - 2 0 0 5. - . 4, 1. - . 2 5 - 3 1.

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1 6 ) ( p 1 1 : p 1 3 ), in a patient with the variant t ( 8 ;

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2 0 7. G r e e n, P.J. A c u t e m y e l o g e n o u s l e u k e m i a / P.J. G r e e n, R.M. Baer, C M. K i n n e y // W i n t r o b e ' s clinical h e m a t o l o g y. 10 e d. / E d. by G.R. L e e. - 1 9 9 9. P. 2 2 7 2 - 2 3 2 0.

2 0 8. P h e n o t y p i c a l characteristics of acute m y e l o c y t i c l e u k e m i a a s s o s i a t e d with t h e t ( 8 ;

2 1 ) ( q 2 2 ;

q 2 2 ) c h r o m o s o m a l abnormality: f r e q u e n t e x p r e s s i o n of i m m a t u r e B-cell a n t i g e n C D 1 9 t o g e t h e r with s t e m cell a n t i g e n C D 34 / K. Kita [et al.] // B l o o d. - 1992. V o l. 8 0. - P. 4 7 0 - 4 7 7.

2 0 9. F e n a u x, P. A c u t e p r o m y e l o c y t i c l e u k e m i a : biology a n d T r e a t m e n t / P. F e n a u x, C h. C h o m i e n n e, L. D e g o s // S e m i n a r s in O n c o l o g y. - 1 9 9 7. - V o l. 2 4. P. 9 2 - 1 0 2.

2 1 0. Langmuir, P.B. A c u t e m y e l o i d l e u k e m i a in c h i l d r e n / P.B. L a n g m u i r, R. A p l e n c, B.J. L a n g e // B e s t practice & R e s e a r c h Clinical H a e m a t o l o g y. - 2 0 0 1 Vol. 1 4 ( 1 ). - P. 77-93.

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2 1 2. D e t e c t i o n of f u s i o n t r a n s c r i p t s g e n e r a t e d by the i n v e r s i o n 16 c h r o m o s o m e in a c u t e m y e l o g e n o u s l e u k e m i a / D.F. Claxton [et al.] // B l o o d. - 1 9 9 4. - V o l. 8 3. P. 1 7 5 0 - 1 7 5 6.

2 1 3. P a r a s k e v a s, F. C l a s t e r s of differentiation / F. P a r a s k e v a s // W i n t r o b e ' s clinical h e m a t o l o g y. 10 e d. / E d. by G.R. Lee. - 1999. - P. 7 2 - 9 2 1 4. T h e i m p o r t a n c e of d i a g n o s t i c c y t o g e n e t i c s o n o u t c o m e in A M L : A n a l y s i s of 1612 patients e n t e r e d into the M R C A M L 10 trial / D. G r i m w a d e [et al.] // B l o o d. 1998. - V o l. 9 2. - P. 2 3 2 2 - 2 3 3 3.

2 1 5. P r e t r e a t m e n t c y r o g e n e t i c a b n o r m a l i t i e s are predictive of i n d u c t i o n s u c cess, c u m u l a t i v e index o f r e l a p s e, a n d o v e r a l l survival in adult patients w i t h d e n o v o acute m y e l o i d l e u k e m i a. R e s u l t s f r o m C a n c e r a n d L e u k e m i a G r o u p ( C A L G B 8 4 6 1 ) / J. Byrd [et al.] // B l o o d. - 2 0 0 2. - V o l. 100. - P. 4 3 2 5 - 4 3 3 6.

2 1 6. P r o g n o s t i c i m p o r t a n c e of c y t o g e n e t i c s u b g r o u p s in d e n o v o p e d i a t r i c a c u t e n o n l y m p h o c y t i c l e u k e m i a / D.K. K a l w i n s k y [et a l ] // J. C l i n, O n c o l. - 1 9 9 0. - V o l. 8. P 75-83.


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2 1 8. B o u l a d, F. T r e a t m e n t of c h i l d h o o d n o n l y m p h o b l a s t i c l e u k e m i a : a r e v i e w / F. B o u l a d, N. K e r n a n // C a n c e r Invest. - 1993. - V o l. 1 1. - P. 5 3 4 - 5 5 3.

2 1 9. R T - P C R for t h e d e t e c t i o n of m i n i m a l resudial d i s e a s e in a c u t e m y e l o b l a s t s leukemia w i t h t(8;

21) a n d t ( 1 5 ;

1 7 ) / J. K r a u t e r [et al.] // A c u t e L e u k e m i a s V I I, E x p e r i mental A p p r o a c h a n d N o v e l T h e r a p i e s. - 1 9 9 8. - P. 1 0 2 0 - 1 0 2 5.

2 2 0. C y t o g e n e t i c a n d clinical c o r r e l a t e s in A M L patients w i t h a b n o r m a l i t i e s of c h r o m o s o m e 16 / P. M a r l t o n [et a l ] // L e u k e m i a. - 1995. - V o l. 9. - P. 9 6 5 - 9 7 1.

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223. Myelodysplastic s y n d r o m e, juvenile myelomonocytic leukemia, and acute myeloid l e u k e m i a a s s o c i a t e d w i t h c o m p l e t e or partial m o n o s o m y 7 / H. H a s l e [et al.] // L e u k e m i a. - 1999. - V o l. 13. - P. 3 7 6 - 3 8 5.

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2 2 5. N a s h e d, A. Clinical a p p l i c a t i o n of B C R / A B L m o l e c u l a r t e s t i n g in a c u t e leu kemia / A. N a s h e d, K. R a o, M. G u l l e y // J. M o l e c u l a r D i a g n o s t i c s. - 2 0 0 3. - V o l. 5. No. 2. - P. 6 3 - 7 2.

2 2 6. C y t o g e n e t i c s, m o l e c u l a r a n d ultrastructural c h a r a c t e r i s t i c s of b i p h e n o t y p i c acute l e u k e m i a identified by t h e E G I L s c o r i n g s y s t e m / T. O w a i d a h [et al.] // L e u k e mia. - 2 0 0 6. - V o l. 2 0 (4). - P. 6 2 0 - 6 2 6.

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2 2 8. T r a n s l o c a t i o n (14;

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2 2 9. B i p h e n o t y p i c A c u t e L e u k e m i a with t(15;

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2 3 1 C a m p a n a, D. Detection of m i n i m a l residual d i s e a s e in a c u t e l e u k e m i a :

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2 3 6. F o l w c y t o m e t r i c f o l l o w - u p of m i n i m a l r e s i d u a l d i s e a s e in b o n e m a r r o w g i v e s p r o g n o s t i c i n f o r m a t i o n in children w i t h a c u t e l y m p h o b l a s t i c l e u k e m i a / E. B j o r k l u n d [et a l. ] / / L e u k e m i a. - 2 0 0 3. - V o l. 1 7. - P. 1 3 8 - 1 4 8.

2. 2.1. - ( 1 9 9 7 - 2 0 0 6 .) 5 2 2 , 21,3 % . , , 3,2 % 100 ( 0 - 1 4 ). - 1,24. , ICCC-0-III, : - 34 ( 6, 5 % ), - 2 0 6 ( 3 9, 5 % ) ;

- 120 (23 % ) ;

- 65 ( 1 2, 5 % ) ;

- 56 (10,7 %) 41 (7,8 %) [ 1, 2].

, , 80 % . (50 % ), ( 2 5 % ) (5-7 %) (. 93).

. 120 [3-6].

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0% 5% 10% 15% 20% 25% - | 0, ] 0, . 93. (, 2007) [7] ICD-O 2 : 9421/1 I 9425/3 II 9384/1 I 9424/3 II : 9400/3 II 9420/3 II 9411/3 II 9410/3 II 9401/3 III : IV 9440/ IV 9441/ 9442/3 IV 9381/3 III 9450/3 II 9451/3 III 9382/3 II . 1 2 III 9382/ 9383/1 I 9394/ I 9391/3 II 9391/3 II 9393/3 II 9391/3 II 9391/3 II 9392/3 III 9390/0 I 9390/1 II 9390/3 III 9430/3 IIV 9444/1 II 9431/1 I - 9493/0 ( - ) 9412/1 / 9413/0 9492/0 9505/1 Ml III 9505/ 9506/ II 9506/1 II 9506/1 II 9509/1 9509/1 8680/ 9361/1 9362/3 ll-lll 9362/3 IV ll-lll 9395/ 9470/3 IV :


IV 9471/ IV 9471/ 9474/3 IV 9474/3 IV : 9473/3 IV 9500/3 IV . 1 9490/3 IV 9501/3 IV IV 9392/ / 9508/3 IV - - 9560/ (, ): I 9560/0 I 9560/0 I 9560/0 I : 9540/0 I 9550/0 I :

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9540/3 II-IV II-IV 9540/ 9540/3 II-IV II-IV 9540/ : 9530/ 9531/0 I () 9532/0 I () 9537/ 9533/0 I 9534/0 I 9530/ I 9530/0 I 9530/0 I 9530/0 I 9538/1 II 9538/1 II 9539/1 II III 9538/ 9538/3 III 9530/3 III , 8850/0 I 8861/0 I 8880/0 I () 111IV 8850/ 8815/0 I lll-IV 8810/ 8830/3 III 8890/0 I 8890/3 IV 8900/0 I 8900/3 lll-IV . 1 9220/0 9220/3 lll-IV 9180/0 9180/3 lll-IV 9210/0 9120/0 9133/1 II 9150/1 II Ml 9150/ lll-IV 9120/ lll-IV 9140/ - 9364/3 IV 8728/ 8728/1 IV 8720/ 8728/3 IV , 9161/ lll-IV 9590/ 9731/3 III lll-IV 9930/ ll-lll 9064/ 9070/3 IV 9071/3 IV IV 9100/ : 9080/ 9080/0 9080/3 ll-lll lll-IV 9084/ 9085/3 lll-IV : 9350/1 9351/1 9352/1 9582/0 9432/1 8291/0 : , , ( ) [5, 8]. .

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1. ( , ).

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