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The analysis of changes of all registered indices on control groups have shown quite small difference in the investigated indices and do not allow to judge about optimizing influence of physical activities on functional condition correction. At the same time synergic effect of physical activities and PLFEC leads to increase in degree of studied indices changes.

Prolonged practice in a graduated physical activity by untrained young men, accompanied with exposure to PLFEC, shows more pronounced changes on all components of regulation in comparison with persons who were not submitted to such influence. The repeated graduated physical activity causes significant, comparing to baseline values, reduction of SAP by 17,001,14 % (from 174,063, mm Hg under single exercise to 144,062,42 mm Hg under repeated exercise). DAP level following repeated physical activity significantly did not differ from values under a single graduated physical activity (decrease by 0,641,28 %, from 70,002,04 mm Hg to 69,381,82 mm Hg). The index of chronotropic heart function on HR size following a repeated graduated physical activity shows significant decrease of heart function by 13,520,80 % in comparison with a single graduated physical activity (from 136,444,71 bmp to 118,134,46 bmp). SBV amount following MBV decrease by 4,070,86 % (from 12818,45738,09 ml/min to 12320,47738,32 ml/min), CI by 4,070,86 % (from 6,670,35 l/minm2 to 6,400,35 l/minm2) and GPVR by 5,781,48 % (from 682,2037,97 dinscm-5 to 644,7139,47 dinscm-5) significantly increased by 10,940,19 % in comparison with a single graduated physical activity (from 93,373,13 ml to 103,583,48 ml) (fig. 1).

Dynamics of integrated indices of blood circulation in trained young men under a repeated graduated physical activity shows absence of significant changes in the level of arterial blood pressure in comparison with indices under a single graduated physical activity. So, SAP level slightly not significant decreases by 0,660,44 % (from 135,001,78 mm Hg to 134,091,76 mm Hg), and DAP by 1,861,32 % (from 65,911,63 mm Hg to 64,551,25 mm Hg). At the same time HR under a repeated graduated physical activity rises slightly, in comparison with indices under a single graduated physical activity by 0,890,98 % (from 81,551,18 bmp to 82,271,46 bmp), that can indicate certain stimulation of mechanisms of system blood circulation regulation by exposure to PLFEC. SBV, MBV and CI values in the trained young men of the main group against the baseline of repeated exercise showed increase by 12,520,32 % (from 125,6915,51 ml to 141,3617,36 ml), by 13,511,07 % (from 10242,261245,27 ml/min to 11508,801303,18 ml/min) and by 13,511,07 % (from 5,310,63 l/minm2 to 5,970,66 l/minm2) respectively following GPVR decrease by 12,981,01 % (from 805,4097,74 dinscm-5 to 695,7380,78 dinscm-5) in comparison with values under a single graduated physical activity (fig. 1).

ISSNͲߠίȠ.2013.80..1..1 Daparture, % untrained trained - - - - HR SAP DAP SBV MBV CI GPVR Fig. 1. PLFEC influence on dynamics of functional condition of blood circulation system of young men organism under a repeated graduated physical activity (% increase in comparison with values under a single decreased physical activity) Indices of vegetative nervous system in untrained young men under a graduated physical activity under exposure to PLFEC decreased significantly: SI by 58,561, % (from 646,966,94 s.u. to 268,1610,52 s.u.), VBI by 52,031,82 % (from 57,791,85 s.u. to 27,711,42 s.u.), IC increased by 0,761,02 % (from 2,560,11 s.u.

to 2,570,09 s.u.) in comparison with indices under a single graduated physical activity that can indicate certain sedative effect of PLFEC influence. At the same time, taking into consideration the data received in control group of untrained young men, available dynamics indicates synergic effect of physical activity and PLFEC influence on optimization of vegetative regulation (fig. 2).

- Daparture, % -20 untrained trained - - - - - SI VBI IC Fig. 2. PLFEC influence on dynamics of neurohumoral mechanisms condition of regulation of young men organism under a repeated graduated physical activity (% increase in comparison with values under a single graduated physical activity) 94 ISSNͲߠίȠ.2013.80..1..1 There was a significant increase in trained young mens SI of cardiovascular system under a repeated graduated physical activity comparing to values under a single graduated physical activity by 9,693,16 % (from 355,285,91 s.u. to 390,1214,34 s.u.), which was accompanied with significant VBI increase by 8,733,01 % (from 52,451,40 s.u. to 56,962,05 s.u.) and significant IC decrease by 9,630,75 % (from 0,590,04 s.u. to 0,540,04 s.u.). Significant increase of SI testifies that exposure to PLFEC, partially stimulating vegetative, allows realizing parasympathetic function (fig. 2).

The index of general physical efficiency in untrained young men made 155,6141,06 kgm/min and corresponded to both low level of organism energy supply conformity to the offered exercise and relative working efficiency, which made 2,433,77 kgm/min/kg Thus, there is general decrease in organism power possibilities against the background of unusual constant physical work that indicates certain exhaustion of power stores. Thereby, on the one hand, low SI and VBI indices described above can be interpreted as additional confirmation of inadequate physical exercise for the given group. On the other hand, comparison of vegetative indices with cardiovascular system parameters can indicate optimization of actual cardiovascular regulation and its optimization under PLFEC use.

The index of general physical efficiency in trained young men made 1773,76280,91 kgm/min (relative physical efficiency 24,743,86 kgm/min/kg) and corresponded to an average level of organism energy supply under the offered exercise.

Processes of restoration after the graduated physical activity, monitored for minutes, in control group of untrained young men show that returning of the basic indices of cardiovascular system to initial values occurred at different times and averaged on HR 2,060,18 min, on SAP 4,350,26 min, on DAP 4,180,23 min, on SBV 8,410,23 min, on MBV, CI and GPVR 8,470,33 min. Indices of vegetative nervous system also showed quite fast returning to norm. SI, VBI and IC reached initial values not later than in 5 minutes (SI on average for 5,350,32 min, VBI on average for 5,240,26 min and IC on average for 5,290,34 min) (fig. 3).

Indices following restoration, registered after each influence in control group of trained young men, indicate slight reduction of restoration time on a vegetative component and absence of changes in time of restoration of the majority of the surveyed indices of cardiovascular system activity. Thus, HR indices were restored in 1,080,08 min, SAP in 1,920,19 min, DAP in 1,750,22 min, SBV in 5,080,23 min, and MBV, CI and GPVR in 4,920,19 min. Indices of vegetative nervous system also showed relatively fast restoration to norm. Thus, SI, VBI and IC reached initial values within 3 minutes (fig. 3).

ISSNͲߠίȠ.2013.80..1..1 Restoration time, min control group of untrained control group of trained HR SAP DAP SBV MBV CI GPVR SI VBI IC Fig. 3. Restoration time of main parameters of organism functional condition of trained and untrained young men in control group Indices following restoration, registered after each influence in the main group of untrained young men, indicate definite optimization of restoration of all studied indices. Attention is attracted to the pronounced effect of PLFEC influence on a vegetative component of organism physiological functions regulation. Dynamics of all studied indices shows unequivocal and unidirectional stabilization of restoration processes after each exposure to both physical activity and PLFEC. Processes of restoration after a repeated graduated physical activity, monitored for 20 minutes, show that returning of the main indices of cardiovascular system to initial values occurred at different times and averaged on HR 1,510,19 min, on SAP 3,440,19 min, on DAP 3,310,19 minute, on SBV 7,130,27 min, on MBV, CI and GPVR 7,250,38 min. Indices of vegetative nervous system also showed quite fast returning to norm: SI for 4,560,37 min, VBI 4,380,26 min, IC for 4,540,34 min (fig. 4).

Indices following restoration, registered after each influence in the main group of trained young men, indicate considerable significant reduction of restoration time on a vegetative component and indices of system blood circulation. Processes of restoration after a repeated graduated physical activity, monitored for 20 minutes, show that returning of the main indices of cardiovascular system to initial values averaged on HR 0,790,09 min, on SAP 1,210,21 min, on DAP 1,130, min, on SBV 3,820,23 min, on MBV, CI, GPVR 3,910,25 min. Indices of vegetative nervous system also showed quite fast returning to norm: SI 2,670, min, VBI for 2,580,18 min, IC for 2,410,21 min (fig. 4).

Thus, optimizing PLFEC effect on the trained organism in greater degrees covers the cardiac component that is expressed in significant increase of contractile heart function and volume indices of blood circulation. Following general optimization of system haemodynamics, young sportsmen keep stable regulation of vegetative functions and stably high general physical efficiency usual for people who do physical exercise regularly.

96 ISSNͲߠίȠ.2013.80..1..1 R e s to ra tio n tim e, m in 6 main group of untrained main group of trained HR SAP DAP SBV MBV CI GPVR SI VBI IC Fig. 4. Restoration time of main parameters of functional condition organism functional condition of trained and untrained young men of main group In untrained young men optimization process in greater degree covered vegetative indices, which can be regarded as additional positive influence of PLFEC on processes of organism adaptation to such stress influence which physical activity is. It is quite clear, that it is obviously impossible to improve indices of the general physical efficiency essentially during such a short time interval, but improvement of restoration parametres allows considering the use of such influence as corrective means which allows intensification of adaptation to physical exercise with people who lead sedentary life.

Comparing the data obtained in control and main groups, it is possible to draw a conclusion that the given influence promotes maintenance of high level of working capacity in people who do sports, due to increase in cardiovascular system efficiency following restoration processes improvement while in untrained people influence promotes leveling of hypodynamia functional displays including psychoemotional pressure removal.

The obtained data have allowed to generalize some aspects of physiological mechanism of PLFEC influence on functional condition of untrained young men organism and to specify systems in which there is the most expressed reaction to the specified influence (fig. 5).

ISSNͲߠίȠ.2013.80..1..1 Fig. 5. The mechanism of PLFEC influence on the general physical efficiency of untrained young men.

As there are certain differences in the mechanism of PLFEC influence on functional condition of an organism of untrained and trained young men, we also made generalization of PLFEC influence on trained young men functional condition (fig. 6).

Fig. 6. The mechanism of PLFEC influence on the general physical efficiency of trained young men 98 ISSNͲߠίȠ.2013.80..1..1 CONCLUSIONS 1. It has been found that PLFEC influence carries out regulating influence on physiological systems of young men organism following physical activities and has character of cardiovascular system activity and vegetative functions optimization.

2. PLFEC influence on healthy young man who do not sports has positive influence of physical activities, optimizing system blood circulation due to vegetative nervous system activity level.

3. PLFEC influence on trained young men organism is represented in significant increase in cardiotropic function, optimization of system blood circulation indices, stabilization of vegetative nervous system regulation. In trained healthy young men PLFEC influence is synergic to effects from exercise amount that proves to be true by indices of system blood circulation.

4. PLFEC influence is displayed in optimization of cardiovascular and vegetative nervous systems indices in the period of restoration against the background of significant reduction of restoration time.

5. PLFEC influence on general physical efficiency is shown in increase of index W170.

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: (), , , A.V.ovalyova, O.V.Kovalyova DISTINCTIONS IN ORIENTATION OF PULSE LOW-FREQUENCY ELECTRIC CURRENT INFLUENCE ON CARDIOVASCULAR SYSTEM FUNCTIONAL CONDITION AT TRAINED AND UNTRAINED PERSONS Studies of changes of organism functional condition following exposure to pulse low-frequency electric current (PLFEC) are extremely insufficient. There are few ISSNͲߠίȠ.2013.80..1..1 data, which were received in different conditions and on different tool base and which are not systematized.

The aim of the study was to compare the characteristics of a pulse low-frequency electric current influence on cardiovascular system functional condition in trained and untrained persons (17-24 years old) during the physical activity and restoration.

The study included 56 healthy young men (23 trained and 33 untrained), who were divided into the main group (11 trained and 16 untrained persons) and control group (12 trained and 17 untrained persons).

The study included two stages: the first stage the baseline functional condition was estimated in both groups;

the second stage the functional condition state reaction to repeated pulse low-frequency electric current during the physical activity was recorded. The pulse low-frequency electric current influence was produced using the device LEIT. The results suggest that the pulse low-frequency electric current carries out regulating influence on physiological systems of young men during the physical activity and has the character of cardiovascular system activity optimization and vegetative functions optimization.

Key words: pulse low-frequency electric current, functional condition, trained young men, untrained young men, physical efficiency :796.012.1:[615.015.4] . . Ҳ òί IJ ò Ҳ Բ : , , .

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L. I. Levchenko Zaporozhye State Medical University PECULIARITIES OF PHARMACOLOGICAL EFFECTS OF MACROERGIC PHOSPHATES AT HARASSING PHYSICAL EXERTIONS Harassing physical exertions at sportsmen's leads to ischemically-anoxic damage of different organs and tissues of the body.

Investigation was conducted on the Wistar albino rats (weight 200-220 gr).

Rats were housed in vivariums with natural light cycle and on the standard vivariums food ration. Swimming test was included weight load, which was corresponded to 8% of rat body mass.

One hour before the swimming test Creatinphosphate (Neoton, dose mg/kg) was administered to the rats of the main group intraperitoneally. After swimming until "to refusal" animals were taken out from the experiment.

Following biochemical parameters were investigated: isoforms activity (MM, MB, BB), creatinephosphokinase (CPK), hexokinase (HK), succinatedehydrogenase (SDG), adenosinetriphosphate, adenosinediphosphate and Adenosine monophosphate (ATP, ADP, AMP) acids.

It was revealed, that Neoton significantly decreases ischemic cardiac hystiocyte membrane damage, improves function with "shuttle Sax1 phenomenon" with increasing of intracellular cretinkinase reacrions, which improves ATP transport.

Key words: harassing physical exertions, of macroergic phosphates, neoton.

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ISSNͲߠίȠ.2013.80..1..1 3. Akcetin Z., Zugor ., Elsasser D. Does the distance to normal renal parenchyma (DTNRP) in nephron-sparing surgery for renal cell carcinoma have an effect on survival? // Anticancer Res. - 2005. - Vol.25,N3A. - .629-632.

4. Hafez K.S, Fergany A.F., Novick A.C. Nephron sparing surgery for localized renal cell carcinoma: impact of tumor size on patient survival, tumor recurrence and TNM staging //J. Urol. - 1999. - Vol.162, N6. - P.1930-1933.

5. Jescbke K., Peschel R., Wakonig L. et al. Laparoscopic nephron-sparing surgery for renal tumors // Urology. - 2001. - Vol. 58. - P. 688-692.

6. Leibovich B.C, Blute M.I., Cheville J.C. Nephron sparing surgery for appropriately selected renal cell carcinoma between 4 and 7 cm results in outcome similar to radical nephrectomy //J. Urol. - 2004. - Vol.171, N3. - P.1066-1070.

7. Li Q.L., Guan H.W., Zhang Q.P. Optimal margin in nephron-sparing surgery for renal cell carcinoma 4 cm or less // Europ. Urol. - 2003. - Vol.44, N4. - P.448 451.

8. Meng M.V., Freise .E., Stoller M.L. Laparoscopic nephrectomy, ex vivo excision and autotransplantation for complex renal tumors //J. Urol. - 2004. Vol.172, N2. - .461-464.

9. Patard J.J., Shvarts O., Lam J.S. Safety and efficacy of partial nephrectomy for all T1 tumors based on an international multicenter experience //J. Urol.- 2004. Vol.171(6 Pt 1). - P.2181-2185, quiz 2435.

10. Piper N.Y., Bisboff J.T., Magee C. Is a 1-CM margin necessary during nephron-sparing surgery for renal cell carcinoma? // Urology. - 2001. - Vol.58, N6. P.849-852.

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O.O.Lyulko, O.O.Burnaz, I.M.Nikituk, O.S.Sagan State Institution "Zaporozhye Medical Academy of Postgraduate Education Ministry of Health of Ukraine " LAPAROSCOPIC RENAL CANCER ORGAN-SAFETY TREATMENT The purpose of the study was to analyze the long-term results of treatment of patients with kidney cancer in stage T1-2 NoMo after you have made sparing surgery (partial nephrectomy) in 127 patients.

When you select method of access and partial nephrectomy should consider the location and size of tumors. Most authors prefer laparoscopic access, mainly growing on extra. Extracorporeal partial nephrectomy may be recommended in situations where performance of nephron-sparing surgery in corpore technically not possible, in the presence of a large tumor, its localization in the central regions of the kidney, intraparenchymal growth, as well as multiple lesions. In other cases, the abdominal resection of the kidney in situ.

For the purpose preserving therapy for multiple tumor foci, large tumor masses, hard-to-resection localization technique is used extracorporeal partial nephrectomy followed by autologous transplantation.

The remote results Analysis of organ-safety surgical treatment of 67 Renal Cancer T1-2N0M0 patients (kidney resection) has allowed to do the following findings.

The Absolute indications to resections is double-sided lesions in stage T1-2N0M0, as well as single or single functionning kidney. The radical resection is possible at size of the extrarenal tumors not more than 7 cm.

The radical resection is possible at size of the intrarenal tumors not more than 5 cm. Post resection at stage T1-2 5 year non-recidive period and survivability was 89,6%. It allows to say about kidney resection results do not yield such after radical nephrectomy.

Key words: renal cancer, kidney resection, resection border, ischemia time.


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ISSNͲߠίȠ.2013.80..1..1 A.A. Lyulko, N.S. Lutsenko, I.A. Evtereva, V.Y. Potebnya State Institution "Zaporozhye Medical Academy of Postgraduate Education Ministry of Health of Ukraine " FEATURES CONTRACTILE ACTIVITY OF THE PELVIC FLOOR MUSCLES IN THE EARLY POSTPARTUM PERIOD Introduction. During pregnancy and childbirth a woman's body undergoes stress on MPF, thats results in the postpartum period. These changes are associated with the passage of the fetus through the birth canal, and as a consequence, increase the size of the vagina, the weakened by the force of contraction of muscles of the urogenital diaphragm. The above phenomena can lead to complications such as urinary incontinence, pelvic organ prolapse, dyspareunia, anorgasmia, decreased libido The process of development of these long-term complications. However, unfortunately, as prolapse of pelvic organs, and urinary incontinence are identified in the later stages of the disease, which makes the possibility of curing patients, prevention of recurrence minimal.

Materials and methods. In this study of contractile power(CP) of muscles of pelvic floor (MPF) was used pneumatic device Muranivskogo. For the study were taken the following groups of patients: group number :1 - the patient, delivery by caesarean section (CS), which do not have a history of vaginal delivery, the group number 2 (basic) - patient giving birth vaginally (ERP) in which included two subgroups: subgroup 2.1-in violation of the integrity of the MTD and the subgroup 2.2-without breaking the MTD, the group number 3 were nulliparous patient. The total number of patients was 130 women.

Results and their discussion. In the group number 1 were taken 29 patients, consisting of 22.3% of the total number of researched women;

in the group 2.1, the number of patients was 43 patients and 33.1% of the total number of examined patients;

in the group 2.2, there are 28 patients that amounted to 21.5% of the total number examined;

in the group number 3 - 30 patients, representing 23.1% of women studied. It is clear that the subgroup 2.1- patients, giving birth through ERP - in violation of the integrity of the MPF, is the largest group in the number of patients, 43 women, and other groups have approximately the same number of patients.

Pressure sensor of device Muranivskogo injected into the top of the vaginal canal patients group number 1, 2, lying on your back with your knees bent. After that, the pressure gauge exhibited an initial pressure of 20 mm Hg The patient squeezing the vaginal muscles to hold the sensor. In subsequent attempts to remove the probe were carried out at 40,50,60 mm Hg or more. The objective considered minimum figures the pressure at which the patient is kept sensor vaginal muscles. In the control group (group number 3) the initial pressure of the pneumatic device Muranivskogo been exposed to 0 mm Hg In subsequent attempts to remove the probe were performed at 0,10,20 mm Hg or more.

The results showed that the nulliparous patients (control group), the force reduction MPF was on average 5 mm Hg and is the physiological norm CP MPF, as patients in this group hadnt a history of childbirth and the CS. The group included 122 ISSNͲߠίȠ.2013.80..1..1 the number one patient, delivery by CS. In this group, CP MPF averaged 50 mm Hg, indicating that the patients after the operation CS PC MPF reduced 10 times as compared with physiological norm, which, on average, is 5 torr. These data suggest that, despite the absence of the patients in this group in the history of vaginal childbirth, pregnancy (the pressure of the fetus on the MPF) and hormonal changes (increased progesterone) during pregnancy have an effect on the PC MPF, weakening it. The group consisted of patient number 2, giving birth through natural the birth canal in violation of the integrity of the muscles of the perineum (the subgroup 2.1) and without (subgroup 2.2). These subgroups PC MPF averaged 82 and mm Hg, respectively, indicating that that these subgroups of patients PC MPF reduced 16 times as compared with physiological norms. These data also suggest that the passage of the fetus through the birth canal is accompanied by a pronounced decrease in muscle tone, until they are completely refractory, so that the resulting muscle injury has practically no effect on their contractile activity. This is confirmed by the absence of significant differences in muscle strength (82 and 83mm Hg, respectively). While the severity of violations after CS PC MPF lower by 66.0% Conclusion.

1. Normally, the force of contraction of the pelvic of the day varies from 0 to 20 mm Hg 2.Change of hormonal levels associated with pregnancy and fetal effects of prolonged mechanical cause functional changes in the pelvic floor muscles, which is manifested by reduced their contractile activity, on average, 10 times.

3.Prohozhdenie fetus through the birth canal reinforce violation of contractile muscle activity (16 times) until they are fully refractory.

4.Neobhodimy further research to study the physiological period of recovery of contractile activity of the pelvic floor, determine whether prevention of disorders and rehabilitation measures.

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